Crosstalk between Phospholipase D and Sphingosine Kinase in Plant Stress Signaling
نویسندگان
چکیده
The activation of phospholipase D (PLD) produces phosphatidic acid (PA), whereas plant sphingosine kinase (SPHK) phosphorylates long-chain bases to generate long-chain base-1-phosphates such as phytosphingosine-1-phosphate (phyto-S1P). PA and phyto-S1P have been identified as lipid messengers. Recent studies have shown that PA interacts directly with SPHKs in Arabidopsis, and that the interaction promotes SPHK activity. However, SPHK and phyto-S1P act upstream of PLDα1 and PA in the stomatal response to abscisic acid (ABA). These findings indicate that SPHK/phyto-S1P and PLD/PA are co-dependent in the amplification of lipid messengers, and that crosstalk between the sphingolipid- and phospholipid-mediated signaling pathways may play important roles in plant stress signaling.
منابع مشابه
Regulation of phospholipase D by sphingosine involves both protein kinase C-dependent and -independent mechanisms in NIH 3T3 fibroblasts.
Previously, the protein kinase C (PKC) inhibitor sphingosine was found to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) in NIH 3T3 fibroblasts [Kiss & Anderson (1990) J. Biol. Chem. 265, 7345-7350]. Here we examined the possible relationship between the opposite effects of sphingosine on PKC-mediated protein phosph...
متن کاملPhosphatidylinositol 3-Kinase Protein Kinase C, ERK1/2, and Phosphatidylinositol Phospholipase C, Sphingosine Kinase-Mediated Activation of a Mycobacterial Infection Is Dependent on Macrophage's Proinflammatory Response to
متن کامل
Calcium signalling: Sphingosine kinase versus phospholipase C?
A recent study shows that sphingosine kinase and its lipid product have an essential signalling function; they act in the mobilization of calcium ions in antigen-stimulated mast cells. This finding may have relevance to signalling in other cells of the immune system.
متن کاملSphingosine kinase 1 is an intracellular effector of phosphatidic acid.
Sphingosine kinase 1 (SK1) phosphorylates sphingosine to generate sphingosine 1-phosphate (S1P). Because both substrate and product of the enzyme are potentially important signaling molecules, the regulation of SK1 is of considerable interest. We report that SK1, which is ordinarily a cytosolic enzyme, translocates in vivo and in vitro to membrane compartments enriched in phosphatidic acid (PA)...
متن کاملTumor necrosis factor-alpha induces stress fiber formation through ceramide production: role of sphingosine kinase.
Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that activates several signaling cascades. We determined the extent to which ceramide is a second messenger for TNF-alpha-induced signaling leading to cytoskeletal rearrangement in Rat2 fibroblasts. TNF-alpha, sphingomyelinase, or C(2)-ceramide induced tyrosine phosphorylation of focal adhesion kinase (FAK) and paxillin, and ...
متن کامل